Showing posts with label genetics. Show all posts
Showing posts with label genetics. Show all posts

20160425

Plato, Nazism, CRISPR: The long shadow of eugenics




Eugenics is inextricably linked in the public consciousness to Nazi policies of sterilisation and euthanasia. But the concept of hereditary human improvement didn't vanish after the war. Is gene editing technology its modern manifestation? Amanda Smith investigates.

Going back to the ancient Greeks, it was all about breeding. In his Republic, Plato suggests that people should only be allowed to marry under controlled circumstances.

Plato, you see, regarded people much the same as livestock: you breed the best ones and not the others.

There's a new group out there who are unashamedly saying it's not that eugenics was wrong, it's that it was done wrong.

'A lot of people trace the idea of eugenics back to that,' says Nathaniel Comfort, author of The Science of Human Perfection. 'It has a certain logic to it.'

The term 'eugenics' was coined by 19th century British polymath Francis Galton.

'At first he called it viticulture, and then he decided that eugenics was a more euphonious word,' says Comfort. The root of the word is the Greek eugenes, meaning 'well born'...

http://www.abc.net.au/radionational/programs/bodysphere/long-shadow-of-eugenics/7329050

20130611

Wiki: Genetic engineering

Genetic engineering, also called genetic modification, is the direct manipulation of an organism's genome using biotechnology. (Indirect genetic modification through artificial selection has been practiced for centuries.) New DNA may be inserted in the host genome by first isolating and copying the genetic material of interest using molecular cloning methods to generate a DNA sequence, or by synthesizing the DNA, and then inserting this construct into the host organism. Genes may be removed, or "knocked out", using a nuclease. Gene targeting is a different technique that uses homologous recombination to change an endogenous gene, and can be used to delete a gene, remove exons, add a gene, or introduce point mutations.

An organism that is generated through genetic engineering is considered to be a genetically modified organism (GMO). The first GMOs were bacteria in 1973; GM mice were generated in 1974. Insulin-producing bacteria were commercialized in 1982 and genetically modified food has been sold since 1994. Glofish, the first GMO designed as a pet, was first sold in the United States December in 2003.[1]

Genetic engineering techniques have been applied in numerous fields including research, agriculture, industrial biotechnology, and medicine. Enzymes used in laundry detergent and medicines such as insulin and human growth hormone are now manufactured in GM cells, experimental GM cell lines and GM animals such as mice or zebrafish are being used for research purposes, and genetically modified cropshave been commercialized...

http://en.wikipedia.org/wiki/Genetically_modified

20110228

New portable DNA screener to debut this summer

The Homeland Security Department this summer plans to begin testing a DNA analyzer that's small enough to be easily portable and fast enough to return results in less than an hour.

The analyzer, about the size of a laser printer, initially will be used to determine kinship among refugees and asylum seekers. It also could help establish whether foreigners giving children up for adoption are their parents or other relatives, and help combat child smuggling and human trafficking, said Christopher Miles, biometrics program manager in the DHS Office of Science and Technology.

Only DNA can positively determine family relationships, Miles said Wednesday during a conference on biometrics and national security.

Eventually, the analyzer also could be used to positively identify criminals, illegal immigrants, missing persons and mass casualty victims, he said.

The machine, known as a rapid DNA screener, is expected to cut days or weeks and hundreds of dollars off the per-use cost of DNA analysis.

Using a process called digital microfluidics, the analyzer processes a DNA sample and provides results in less than an hour for under $100 per sample, Miles said. By comparison, it takes days or weeks and about $500 per sample to get results when DNA is tested in a laboratory, he said.

"We're not about advancing the technology so much as integrating and automating it into a fieldable device," he said.

Boston-based NetBio, which developed the rapid DNA analyzer for DHS, described it as a "game-changing technology" platform that "consists of instruments, biochips and analytical software." It eliminates the need for a trained technician and special operating site.

The analyzer was designed for Homeland Security, the military, intelligence and police agencies, the company says on its website.

As with other DNA tests, the process begins with a sample collected on a swab, typically from inside the mouth. The sample is placed in a disposable cartridge, and the analyzer does the rest of the work.

"It's the same process that occurs in the lab today," Miles said. But "it will drastically make the system more efficient."

DHS' Citizen and Immigration Services bureau is first in line to begin testing the new equipment this summer. A likely priority is testing people who claim to be family members in refugee camps overseas, Miles said.

That's important because when a refugee is allowed to come to the United States, parents, children and some siblings also could be eligible to enter. Citizen and Immigration Services wants to make sure those who claim to be relatives actually are, he said.

Similarly, the agency wants to make sure children are who their guardians claim them to be. Usually, that sort of identity check might be done with fingerprints, but fingerprints of small children can be unreliable, Miles said.

On an average day, 400 refugees apply to enter the United States, 40 persons are granted asylum and 100 foreign-born children are adopted, according to DHS.

Although DNA analysis speeds identification of people, it raises concerns about privacy and civil liberties, Miles conceded. "We have privacy officers and civil rights and civil liberties officers who are working through all of those questions."

As a precaution to protect privacy, the analyzer avoids sampling DNA that could identify genetic problems, Miles said. For years, privacy advocates have worried that DNA test results could be used to deny people employment, insurance or entry to the country.

But even the analysis DHS officials want to do could be problematic. DNA test results might reveal that a child is not related to the man thought to be his father. "Is it our role to tell them that?" Miles asked. In some societies, revealing such information could be dangerous to the child and its mother, he said.

Policy hasn't developed as fast as technology when it comes to DNA analysis, Jim Harper, director of information studies at the libertarian Cato Institute, told Nextgov. "There are still a lot of unknowns. I'm not certain we know what all is being gathered when we examine DNA." So far, there has been no comprehensive public discussion of what is being gathered, and how it should or shouldn't be used has not occurred, he said.

The machines are expected to cost about $275,000 apiece, Miles said. "That sounds like a lot of money, but compare that to a laboratory full of equipment that would cost millions of dollars and a building that would cost tens of millions of dollars."

After the rapid analyzers are in production, he added, the cost is likely to come down.

20110123

JASONs Ponder Military Role in Gene Research

The technology for sequencing human DNA is advancing so rapidly and the cost is dropping so quickly that the number of individuals whose DNA has been mapped is expected to grow “from hundreds of people (current) to millions of people (probably within three years),” according to a new report to the Pentagon (pdf) from the JASON defense science advisory panel.  The Defense Department should begin to take advantage of the advances in “personal genomics technology” by collecting genetic information on all military personnel, the panel advised.

The cost of sequencing complete human genomes has been falling by about a factor of 30 per year over the last six years, the JASONs said.  As a result, “it is now possible to order your personal genome sequenced today for a retail cost of under ~$20,000″ compared to around $300 million a decade ago.  “This cost will likely fall to less than $1,000 by 2012, and to $100 by 2013.”

“At costs below $1,000 per genome, a number of intriguing applications of DNA sequencing become cost effective.  For example, researchers will have access to thousands or even millions of human genomes to seek correlations between genotypes [i.e. the genetic makeup of individuals] and phenotypes [i.e, the expression of genetic information in observable traits].”

Currently, the understanding of “the linkages between the genotypes of individuals and their phenotypes is limited.”  But “the explosion of available human genome sequence data will provide researchers from academia and industry with the genetic information necessary to conduct large-scale efforts to link genetic markers with human traits.”

For military purposes, it will be up to the Department of Defense “to determine which phenotypes… have special relevance to military performance and medical cost containment” and then presumably to select for those.  “These phenotypes might pertain to short- and long-term medical readiness, physical and medical performance, and response to drugs, vaccines, and various environmental exposures…. More specifically, one might wish to know about phenotypic responses to battlefield stress, including post-traumatic stress disorder, the ability to tolerate conditions of sleep deprivation, dehydration, or prolonged exposure to heat, cold, or high altitude, or the susceptibility to traumatic bone fracture, prolonged bleeding, or slow wound healing.”

“Both offensive and defensive military operations may be impacted by the applications of personal genomics technologies through enhancement of the health, readiness, and performance of military personnel.  It may be beneficial to know the genetic identities of an adversary and, conversely, to prevent an adversary from accessing the genetic identities of U.S. military personnel.”

What could possibly go wrong?  Quite a few things, actually.  Besides the risk of failing to maintain the privacy and security of genetic data, the data could be used in unethical ways or their significance could be misinterpreted.  “Acting on genotype information that is not convincingly linked to specific phenotypes could lead to erroneous and detrimental decision making,” the JASONs said.

In any case, the JASONs advised the Pentagon, “The DoD should establish policies that result in the collection of genotype and phenotype data…. The complete diploid genome sequence for all military personnel should be collected” along with other related information.

A copy of the JASON report was obtained by Secrecy News.  See “The $100 Genome: Implications for the DoD,” JASON Report No. JSR-10-100, December 2010.

This entry was posted on Thursday, January 13th, 2011 at 10:37 am by Steven Aftergood and is filed under Secrecy. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.