Wiki: SV40 (Simian vacuolating virus 40)

SV40 is an abbreviation for Simian vacuolating virus 40 or Simian virus 40, a polyomavirus that is found in both monkeys and humans. It was named for the effect it produced on infected green monkey cells, which developed an unusual number of vacuoles. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors in animals, but most often persists as a latent infection.

SV40 discovery revealed that between 1955 and 1963 around 90% of children and 60% of adults in USA were inoculated with SV40-contaminated polio vaccines.[1]...

...The hypothesis that SV40 might cause cancer in humans has been a particularly controversial area of research.[11] Several methods have detected SV40 in a variety of human cancers, although how reliable these detection methods are, and whether SV40 has any role in causing these tumors, remains unclear.[12] As a result of these uncertainties, academic opinion remains divided, with some arguing that this hypothesis is not supported by the data[13] and others arguing that some cancers may involve SV40.[...

...An analysis presented at the Vaccine Cell Substrate Conference in 2004[28] suggested that vaccines used in the former Soviet bloc countries, China, Japan, and Africa, could have been contaminated up to 1980, meaning that hundreds of millions more could have been exposed to the virus unknowingly.

Population level studies show no evidence of any increase in cancer incidence as a result of exposure,[29] though SV40 has been extensively studied.[30] A thirty-five year followup found no excess of the cancers putatively associated with SV40.[31].


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