20110131

WTF is Ustekinumab?

"...CNTO 1275 is designed to interfere with the triggering of the body's inflammatory response through the suppression of certain cytokines. Specifically, CNTO 1275 blocksinterleukin IL-12 and IL-23 which help activate certain T-cells....

...According to information provided by Centrocor, maker of one medication based on ustekinumab, their version of the drug is associated with several types of serious adverse effects. These include an increased risk of infection, such as by tuberculosisand an increased risk of certain types of cancer. As with some other immunosuppressant drugs like cyclosporine, the brain swelling of posterior reversible encephalopathy syndrome is a risk. The pharmaceutical company also reports seriousallergic reaction as a possible side effect. More common side effects are upper respiratory infection, headache, and tiredness..."

http://en.wikipedia.org/wiki/Ustekinumab

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